Ophtalmic Drug Delivery Systems: Second Edition, Revised and Expanded

Ophtalmic Drug Delivery Systems: Second Edition, Revised and Expanded

Ashim Mitra

ISBN: 0824741242 - 2003

English -Pdf - Size: 9,75 Mb

Ophthalmic Drug Delivery Systems presents new and comprehensive chapters on anterior and posterior segment microdialysis, ocular drug delivery, and ophthalmic formulation design.

It examines the lates strategies in gene therapy, ocular microdialysis, vitreous drug disposition modeling, and receptor/transporter targeted drug delivery.

Contents

Fundamental Considerations

Overview of Ocular Drug Delivery

Membrane Transport Processes in the Eye

General Considerations in Ocular Drug Disposition

Transport Models in Ocular Drug Delivery

Ocular Drug Transfer Following Systemic Drug Administration

Ocular Pharmacokinetics and Pharmacodynamics

Mathematical Modeling of Drug Distribution in th Vitreous Humour

Anterior Segment Microdialysis

Posterior Segment Microdialysis

Drug Delivery Systems

Part A: Conventional Systems

Ocular Penetration Enhancers

Corneal Collagen Shields for ocular Delivery

The Non-Corneal Route in Ocular Drug Delivery

Ocular Iontophoresis

Mucoadhesive Polymers in Ophthalmic Drug Delivery

Microparticulates and Nanoparticles in Ocular Drug Delivery

Dendrimers: An Innovative and Enhanced Ocular Drug Delivery System

Part B: Delivery of Macromolecular Therapeutic Agents

Ocular Delivery and Therapeutics of Peptides and Proteins

Retinal Disease Models for Development of Drug and Gene Therapies

New Experimental Therapeutic Approaches for Degenerative Diseases of the Retina

Gene Oligonecleotide and Ribozyme Therapy in the Eye

Regulatory Aspects

Regulatory Considerations

Patent Considerations

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