Asymmetric Organic Synthesis with Enzymes by: Vicente Gotor, Ignacio Alfonso, Ed

Asymmetric Organic Synthesis with Enzymes by: Vicente Gotor, Ignacio Alfonso, Eduardo García-Urdiales

Publisher: Wiley-VCH | February 2008 | ISBN: 3527318259 | Pages: 326 | PDF | 2.91 MB

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more.

Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Allowing chemists to improve their own yields, this book covers all important reactions. The first part presents new innovative methods for enzymatic catalysis optimization, while the second and main section shows important reaction types and their applications.

From the contents

METHODOLOGY

Medium Engineering:

Directed evolution:

The search for new enzymes:

SYNTHETIC APPLICATIONS

Dynamic Kinetic Resolutions:

Deracemization and Enantioconvergent Processes:

Transesterification and hydrolysis of carboxylic acid derivatives, alcohols and epoxides

Aminolysis and ammonolysis of carboxylic acid derivatives:

Reduction Reactions:

Oxidation Reactions:

Making and breaking C-C bonds:

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