The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation

The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance

Publisher:Springer | Pages:336 | 2009-06-12| ISBN 0387927077 | PDF | 6 MB

The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the

genesis and the maintenance of synaptic connections. Genes encoding adhesive

molecules make up a significant portion of the human genome, and neural

CAMs even have been postulated to be a major factor in the evolution of the

human brain.

Credits to original uploader

Free mirror provided - so Follow the rules - No More Mirrors