Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

by Ram I. Mahato

ISBN: 0849323347 -712 pages-Year 2005

English -Pdf - Size: 27,44 Mb

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids discusses the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles.

Features:

Combines an overview of the principles of polymer science and chemistry with the basic biology required to understand how biomaterials can be used as drug-delivery vehicles

Goes beyond simple discussion of polymers to include information on their design and synthesis

Includes information on biocompatibility, which is essential for understanding polymeric delivery of drugs

Features contributions from leading experts in polymer science and drug delivery worldwide

Contents

• Structures, Properties, and Characterization of Biomaterials

• Step-Reaction and Ring-Opening Polymerization

• Copolymer, Block Copolymers Stimuli-Sensitive Polymers

• Polymer Solution Properties, Polymer Networks

• Protein Conjugation, Cross-linking and PEGylation

• Complement Activation by Injectable Polymeric Carriers

• Biological Membranes and Barriers

• Pharmacokinetics of Proteins and Nucleic Acid Drugs

• In Vivo Fate of Polymeric GENE Carriers

• Subcellular Fate of sProteins and Nucleic Acids

• Stability of Proteins and Nucleic Acids

• Formulation, Stability and Characterization of Protein and Peptide Drugs

• Micro- and Nanoparticulate Polymeric Delivery Systems for Nucleic Acid-based Medicines

• Liposomal Delivery Systems of Proteins and Peptide Drugs

• Mechanisms of Cellular Drug Resistance and Strategies to Overcome It

• Transporters as Molecular Targets for Drug Delivery and Disposition

• Protein Transduction Domains as a Novel Tool for Delivery of Protein, Peptides and Nucleic Acids

• Introduction to Therapeutic Nucleic Acids

• Antisense and Antigene Oligonucleotide Delivery

• Artificial Nucleic Acid Chaperones

• Basic Components of Plasmid-Based Gene Expression Systems

• Design Elements of Polymeric Gene Carriers

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