Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Scherin

Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings)

Publisher:Springer

Number Of Pages:276

Publication Date:2007-10

Sales Rank:235362

ISBN / ASIN:3540708529

EAN:9783540708520

Binding:Hardcover

Manufacturer:Springer

Studio:Springer

Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk

of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells,

thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell

proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells

offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end

points.